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Myostatin

Myostatin

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Ultima-MYO
Ultima Pharmaceuticals
MYO
Beligas Pharmaceuticals
Substance Overview and History

Myostatin, also known as growth differentiation factor-8 (GDF-8), is a protein belonging to the TGF-β superfamily that regulates muscle growth by inhibiting proliferation and differentiation of muscle cells. Synthesized as an inactive precursor, it undergoes proteolytic activation to bind the activin type IIB receptor (ActRIIB), initiating pathways that suppress muscle development. Found primarily in skeletal muscle, myostatin also influences cardiac tissue and adipose cells. Its role extends to modulating the Akt/mTOR and FoxO1 pathways, thereby controlling muscle hypertrophy and degradation. Given its regulation of muscle mass, myostatin is a key target for understanding and treating conditions like sarcopenia, cachexia, and neuromuscular disorders.

References:

Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients. 

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is myostatin?
Myostatin, also known as GDF-8, is a protein that acts as a negative regulator of muscle growth by inhibiting muscle cell proliferation and differentiation.
References:

Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients. 

Where is myostatin primarily found?
It is predominantly found in skeletal muscle but is also expressed in cardiac muscle and adipose tissue.
References:

Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients. 

What role does myostatin play in muscle wasting conditions?
Myostatin is linked to conditions like sarcopenia and cachexia, where its increased activity or altered regulation contributes to muscle loss.
References:

Baczek, J., Silkiewicz, M., & Wojszel, Z.B., 2020. Myostatin as a Biomarker of Muscle Wasting and Other Pathologies—State of the Art and Knowledge Gaps. Nutrients.