Combination of two substances: Sildenafil citrate, commonly known as Viagra, selectively inhibits phosphodiesterase type 5 (PDE5), enhancing the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway. Developed in 1989 by Pfizer, it was initially intended for treating cardiovascular conditions like angina, but its profound effects on erectile dysfunction (ED) led to its eventual approval and widespread use. Tadalafil, known as Cialis, is a PDE5 inhibitor developed for erectile dysfunction (ED). Initially researched for cardiovascular use, its long-lasting effects make it unique. Approved in 2003, it provides up to 36 hours of effectiveness, enabling greater spontaneity. Its unique structure offers a longer half-life compared to sildenafil and vardenafil.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
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Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.