Drug-induced kidney stones, including those caused by guaifenesin, present diagnostic challenges due to their high protein matrix. A study of guaifenesin-associated stones revealed a composition of 60% protein and 40% guaiacol. Proteomic studies identified a subset of proteins enriched in the stone matrix and depleted in urine, indicating their involvement in the stone-forming process. This research highlights the role of specific proteins in crystal formation and offers a novel approach for identifying key contributors to nephrolithiasis.
Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.
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Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.
Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.
Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.
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