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Guaifenesin

Guaifenesin

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Guaifenesin 600
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Substance Overview and History

Guaifenesin, a common expectorant, has been linked to rare drug-induced kidney stones, characterized by high protein content that complicates diagnosis. A recent case study revealed that guaifenesin stones contain 60% protein and 40% guaifenesin and its metabolite guaiacol. Proteomic analysis identified 49 proteins in the stone matrix, with nine highly enriched and eight reciprocally depleted in urine, suggesting their active role in stone formation. These proteins likely influence crystal nucleation, growth, and tissue attachment, providing new insights into the mechanisms of drug-related nephrolithiasis.

References:

Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What are Guaifenesin-associated kidney stones?
They are rare drug-induced kidney stones composed of guaifenesin, its metabolite guaiacol, and a high protein matrix, making diagnosis challenging.
References:

Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.

What is the composition of Guaifenesin kidney stones?
These stones are 60% protein and 40% guaifenesin and guaiacol, the drug’s crystalline components.
References:

Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.

Why are Guaifenesin stones difficult to diagnose?
Their high protein content often leads to misclassification as matrix stones, which complicates proper identification and treatment.
References:

Kolbach-Mandel, A.M., Mandel, N.S., Cohen, S.R., Kleinman, J.G., Ahmed, F., Mandel, I.C., & Wesson, J.A. (2017) 'Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation', Urolithiasis.