The discovery of fusidic acid’s efficacy against Mycoplasma genitalium offers hope in managing drug-resistant infections. This antibiotic has been safely used for decades to treat Staphylococcus aureus and is now recognized for its activity against M. genitalium, with bactericidal concentrations comparable to achievable serum levels. Resistance to fusidic acid is rare and linked to specific mutations in the fusA gene, with resistant strains showing impaired growth. As antimicrobial resistance rises, fusidic acid's demonstrated effectiveness highlights its potential to fill a critical gap in current treatment options.
Wood, G.E., Lee, J.W., Peramuna, T., Wendt, K.L., Kim, C.M., Aguila, L.K.T., Calderon, C.L., and Cichewicz, R.H., 2024. The fungal natural product fusidic acid demonstrates potent activity against Mycoplasma genitalium. Antimicrobial Agents and Chemotherapy.
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Wood, G.E., Lee, J.W., Peramuna, T., Wendt, K.L., Kim, C.M., Aguila, L.K.T., Calderon, C.L., and Cichewicz, R.H., 2024. The fungal natural product fusidic acid demonstrates potent activity against Mycoplasma genitalium. Antimicrobial Agents and Chemotherapy.
Wood, G.E., Lee, J.W., Peramuna, T., Wendt, K.L., Kim, C.M., Aguila, L.K.T., Calderon, C.L., and Cichewicz, R.H., 2024. The fungal natural product fusidic acid demonstrates potent activity against Mycoplasma genitalium. Antimicrobial Agents and Chemotherapy.
Wood, G.E., Lee, J.W., Peramuna, T., Wendt, K.L., Kim, C.M., Aguila, L.K.T., Calderon, C.L., and Cichewicz, R.H., 2024. The fungal natural product fusidic acid demonstrates potent activity against Mycoplasma genitalium. Antimicrobial Agents and Chemotherapy.