Fusidic acid

Fusidic acid, a fusidane-type antibiotic, shows potent activity against Mycoplasma genitalium, a pathogen associated with urethritis and pelvic inflammatory disease. Known for its intrinsic and acquired resistance to many antibiotics, M. genitalium poses a significant treatment challenge. Fusidic acid, derived from fungal natural products, inhibits bacterial protein synthesis by targeting elongation factor G. It demonstrates minimum inhibitory concentrations (MICs) of 0.31–4 µg/mL and bactericidal activity at ≥10 µg/mL, with low potential for high-level resistance. This long-used antibiotic, available in oral, topical, and intravenous forms outside the United States, represents a promising option for addressing multidrug-resistant infections.

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