Developed by ICOS Corporation and co-launched with Eli Lilly, tadalafil citrate became the active ingredient in Cialis, an ED medication approved in 2003. It functions by inhibiting the PDE5 enzyme, facilitating better blood flow during arousal. Structurally distinct from sildenafil, tadalafil’s long half-life of 17.5 hours provides a 36-hour therapeutic window. Its success came not only from effectiveness, but also from offering spontaneity, making it the preferred option for many patients over older, shorter-acting treatments.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
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Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.