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Home AstraZeneca AstraZeneca
Beloc 50
Beloc 50 - AstraZeneca

Beloc 50 - AstraZeneca

Brand:
AstraZeneca
Category:
Orals
Substance:
Metoprolol
Dosage:
50 mg/tab
Package:
20 tablets
Price:
$40.00 - $40.00
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Product Overview

Metoprolol has emerged as a critical therapy for AMI, offering more than heart rate control. This β1-adrenergic receptor antagonist targets neutrophils, preventing harmful inflammatory responses during reperfusion. It blocks neutrophil-platelet co-aggregates, key contributors to microvascular obstruction (MVO) and tissue damage. Data from the METOCARD-CNIC trial confirmed metoprolol’s efficacy, with patients experiencing significantly smaller infarct sizes and improved long-term outcomes. This dual-action mechanism enhances its importance in AMI management.

References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications. 

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For detailed information about Beloc 50 by AstraZeneca, consult with your doctor or healthcare professional.

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Active Substances
  • Metoprolol
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Beloc 50 mg 20 Tablets AstraZeneca
AstraZeneca
International
$40.00
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FAQ
What is microvascular obstruction, and how does Metoprolol address it?
MVO occurs when inflammatory plugs, formed by neutrophils and platelets, block blood flow in microcirculation after reperfusion. Metoprolol disrupts these interactions, ensuring better blood flow and reduced tissue damage.
References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications. 

Is Metoprolol effective for inflammation-related heart injuries?
Yes, Metoprolol’s ability to dampen neutrophil-mediated inflammation helps mitigate ischemia/reperfusion (IR) injury, making it a critical intervention during AMI treatment.
References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications. 

What were the findings of the METOCARD-CNIC trial?
The METOCARD-CNIC trial showed that intravenous Metoprolol reduced infarct size and microvascular obstruction in AMI patients by 40%, significantly improving long-term cardiac function.
References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications.