My account
Injectables Orals Peptides Human Growth Hormone SARMs
Sign in
A
Anastrozole
B
Bacteriostatic water Boldenone undecylenate
C
Clenbuterol Clomiphene citrate Cabergoline
D
Drostanolone enanthate Drostanolone propionate Dehydroepiandrosterone (DHEA)
E
Erythropoietin Exemestane
F
Fluoxymesterone
H
Human chorionic gonadotropin Human growth hormone
L
Liothyronine sodium
M
Mecasermin Meldonium Mesterolone Methandienone Methenolone acetate Methenolone enanthate Melanotan-2
N
Nandrolone decanoate Nandrolone phenylpropionate
O
Oxandrolone Oxymetholone
S
Sildenafil citrate Stanozolol
T
Trenbolone enanthate Trestolone acetate Trenbolone acetate Testosterone undecanoate Testosterone propionate Testosterone base and suspension Tadalafil citrate Testosterone cypionate Testosterone enanthate Tamoxifen citrate Turinabol
Y
Yohimbine
Show 164 results
Manufacturers
Categories
Substances
Disagree
Home Substances
Metoprolol

Metoprolol

A-Z
Search for:
Beloc 50
AstraZeneca
Substance Overview and History

Metoprolol, a selective β1-adrenergic receptor blocker, is widely recognized for its role in reducing infarct size and improving cardiac function in acute myocardial infarction (AMI). Beyond its traditional focus on cardiomyocytes, recent research highlights its action on neutrophils. By disrupting neutrophil-platelet interactions and migration, metoprolol reduces inflammation and microvascular obstruction (MVO) during reperfusion. Clinical trials like METOCARD-CNIC show a 40% reduction in MVO, positioning metoprolol as a vital tool in minimizing ischemia/reperfusion (IR) injury and long-term cardiac damage.

References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications. 

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Metoprolol used for?
Metoprolol is a selective β1-adrenergic receptor blocker primarily used to manage hypertension, angina, and heart rhythm disorders. It is also effective in reducing infarct size and improving cardiac outcomes in acute myocardial infarction (AMI).
References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications. 

How does Metoprolol work in the heart?
Metoprolol reduces heart rate and myocardial oxygen demand by blocking β1-adrenergic receptors, helping to manage cardiac conditions like arrhythmias and angina. It also minimizes damage in AMI by reducing ischemia and reperfusion injury.
References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications. 

How does Metoprolol help during a heart attack?
Administered intravenously before reperfusion, Metoprolol reduces neutrophil migration and neutrophil-platelet interactions, preventing microvascular obstruction (MVO) and limiting infarct size.
References:

García-Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García-Lunar, I., Crainiciuc, G., Fernández-Jiménez, R., Sreeramkumar, V., Bourio-Martínez, R., García-Ruiz, J.M., Serrano del Valle, A., Sanz-Rosa, D., Pizarro, G., Fernández-Ortiz, A., Hidalgo, A., Fuster, V., & Ibanez, B. (2017) 'Neutrophil stunning by metoprolol reduces infarct size', Nature Communications.