Known for its antioxidant properties, amifostine has emerged as a promising candidate for treating IPF. It combats fibrosis by reducing mitochondrial ROS, restoring oxidative phosphorylation, and rebalancing energy metabolism. By activating SIRT1 and AMPK, it helps maintain mitochondrial function and cellular health. These effects position amifostine as a potential therapy to slow IPF progression and improve patient outcomes.
Guo, F., Xu, F., Li, S., Zhang, Y., Lv, D., Zheng, L., Gan, Y., Zhou, M., Zhao, K., Xu, S., Wu, B., Deng, Z. and Fu, P., 2024. Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism. European Journal of Medical Research
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about Amifostine Crystalline 500 AMPULES by Swiss Remedies, consult with your doctor or healthcare professional.
Guo, F., Xu, F., Li, S., Zhang, Y., Lv, D., Zheng, L., Gan, Y., Zhou, M., Zhao, K., Xu, S., Wu, B., Deng, Z. and Fu, P., 2024. Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism. European Journal of Medical Research
Guo, F., Xu, F., Li, S., Zhang, Y., Lv, D., Zheng, L., Gan, Y., Zhou, M., Zhao, K., Xu, S., Wu, B., Deng, Z. and Fu, P., 2024. Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism. European Journal of Medical Research
Guo, F., Xu, F., Li, S., Zhang, Y., Lv, D., Zheng, L., Gan, Y., Zhou, M., Zhao, K., Xu, S., Wu, B., Deng, Z. and Fu, P., 2024. Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism. European Journal of Medical Research