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Moxifloxacin

Moxifloxacin

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Avelox 400
Bayer
Substance Overview and History

Moxifloxacin is a potent fluoroquinolone antibiotic used primarily in the treatment of multidrug-resistant tuberculosis (MDR-TB). Its mechanism of action involves disrupting bacterial DNA synthesis through inhibition of DNA gyrase, while also inducing oxidative stress that damages cellular components. This dual action causes significant bacterial lethality. Moxifloxacin alters Mycobacterium tuberculosis's redox state, increasing reactive oxygen species (ROS) and reductive stress, contributing to its bactericidal effect. Its efficacy is enhanced by agents like N-acetyl cysteine, which amplify ROS production and improve treatment outcomes.

References:

Shee, S., Singh, S., Tripathi, A., Thakur, C., Kumar T, A., Das, M., Yadav, V., Kohli, S., Rajmani, R. S., Chandra, N., Chakrapani, H., Drlica, K., & Singh, A. (2022). Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species. Antimicrobial Agents and Chemotherapy.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Moxifloxacin used for?
Moxifloxacin is a fluoroquinolone antibiotic used to treat a variety of bacterial infections, including multidrug-resistant tuberculosis (MDR-TB) and certain respiratory and skin infections.
References:

Shee, S., Singh, S., Tripathi, A., Thakur, C., Kumar T, A., Das, M., Yadav, V., Kohli, S., Rajmani, R. S., Chandra, N., Chakrapani, H., Drlica, K., & Singh, A. (2022). Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species. Antimicrobial Agents and Chemotherapy.

How does Moxifloxacin work?
It inhibits bacterial DNA gyrase, blocking DNA replication and repair. Additionally, it induces oxidative stress, producing reactive oxygen species (ROS) that damage bacterial cells, leading to their death.
References:

Shee, S., Singh, S., Tripathi, A., Thakur, C., Kumar T, A., Das, M., Yadav, V., Kohli, S., Rajmani, R. S., Chandra, N., Chakrapani, H., Drlica, K., & Singh, A. (2022). Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species. Antimicrobial Agents and Chemotherapy.

What makes Moxifloxacin effective in MDR-TB treatment?
Moxifloxacin disrupts Mycobacterium tuberculosis’s redox balance, causing oxidative stress and cell death. It is also effective in shortening treatment durations and reducing resistance when combined with other therapies.
References:

Shee, S., Singh, S., Tripathi, A., Thakur, C., Kumar T, A., Das, M., Yadav, V., Kohli, S., Rajmani, R. S., Chandra, N., Chakrapani, H., Drlica, K., & Singh, A. (2022). Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species. Antimicrobial Agents and Chemotherapy.