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Melanotan-2

Melanotan-2 - Page 2

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MELANOTAN II
Keifei Pharma
Substance Overview and History

Penile erection is a complex process which involves the nervous system and vascular functions. Activation of central melanocortin (MC) receptors can trigger spontaneous erections, with MC4 emerging as a key receptor subtype. Historically, the pro-erectile properties of melanocortin compounds were recognized as early as the 1950s, but the MC receptor subtypes' roles in this process have only recently become clearer, providing new insights into treating sexual dysfunctions.

References:

King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is the role of melanocortin (MC) receptors in penile erection?
MC receptors, particularly MC4, play a key role in initiating or enhancing spontaneous penile erections.
References:

King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.

Which melanocortin receptor subtype is most involved in erectile function?
MC4 is emerging as the primary receptor subtype involved in melanocortin-induced erections.
References:

King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.

What was the first discovery linking melanocortin compounds to sexual activity?
Studies in the mid-20th century showed increased sexual excitement in animals after administering melanocortin compounds like α-MSH.
References:

King, S.H., Mayorov, A.V., Balse-Srinivasan, P., Hruby, V.J., Vanderah, T.W., and Wessells, H. (2007). Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry.