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Glucagon-like peptide-1 (GLP-1)

Glucagon-like peptide-1 (GLP-1) - Page 3

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Substance Overview and History

Discovered back in the 1980s, GLP-1 is a peptide hormone, mostly produced in the intestine and brain that helps manage sugar levels by triggering insulin release and curbing glucagon production while slowing down digestion. Traced back to research, on proglucagon from the 1920S GLP-1 now plays a role in treating diabetes and obesity due to its effectiveness in regulating blood sugar levels and curbing hunger. Managing blood sugar and reduce appetite has made it a valuable therapeutic target.

References:

Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is GLP-1?
GLP-1 is a 30-31 amino acid incretin hormone that regulates glucose metabolism and appetite.
References:

Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology

What are the main benefits of GLP-1?
GLP-1 promotes insulin secretion, reduces appetite, lowers blood glucose, and has anti inflammatory effects.
References:

Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology

How does GLP-1 work?
Binds to GLP-1 receptors, activating pathways that regulate insulin, glucagon, and inflammation.
References:

Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology