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Folinic Acid

Folinic Acid

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Leucovorin Calcium 50 AMPULES
Swiss Remedies
Substance Overview and History

Leucovorin (folinic acid) is a reduced form of folate that addresses cerebral folate deficiency (CFD), a condition linked to autism spectrum disorder (ASD) and impaired 5-MTHF transport into the brain via the folate receptor alpha (FRα). Autoantibodies against FRα (FRAAs) are present in 58–76% of individuals with ASD, disrupting folate transport and leading to low cerebrospinal fluid (CSF) folate levels. Leucovorin bypasses this dysfunction by utilizing alternative transport pathways, normalizing CSF folate. Studies reveal significant improvements in ASD symptoms, including communication, attention, and motor function, with 21% of patients achieving full recovery.

References:

Rossignol, D.A., & Frye, R.E. (2021) 'Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis', Journal of Personalized Medicine.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Leucovorin?
Leucovorin, or folinic acid, is a reduced form of folate that bypasses folate metabolism pathways, making it an active and effective treatment for certain conditions like cerebral folate deficiency (CFD).
References:

Rossignol, D.A., & Frye, R.E. (2021) 'Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis', Journal of Personalized Medicine.

What conditions does Leucovorin treat?
Leucovorin is used to treat cerebral folate deficiency (CFD), autism spectrum disorder (ASD) associated with CFD, and to reduce the side effects of folate antagonists like methotrexate.
References:

Rossignol, D.A., & Frye, R.E. (2021) 'Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis', Journal of Personalized Medicine.

How does Leucovorin work in cerebral folate deficiency?
It bypasses dysfunction in the folate receptor alpha (FRĪ±), restoring cerebrospinal fluid (CSF) folate levels and improving neurological and developmental symptoms.
References:

Rossignol, D.A., & Frye, R.E. (2021) 'Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis', Journal of Personalized Medicine.