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Home GlaxoSmithKline (GSK) GlaxoSmithKline (GSK)
Zyban 150
Zyban 150 - GlaxoSmithKline (GSK)

Zyban 150 - GlaxoSmithKline (GSK)

Brand:
GlaxoSmithKline (GSK)
Category:
Orals
Substance:
Bupropion Hydrochloride
Dosage:
150 mg/tab
Package:
60 tablets
Price:
$75.00 - $75.00
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Product Overview

Bupropion hydrochloride serves as a key treatment for major depressive disorder (MDD) and as a smoking cessation aid. It acts by inhibiting norepinephrine and dopamine reuptake, enhancing mood and reducing withdrawal symptoms. The drug is metabolized in the liver, primarily producing 6-hydroxybupropion, which contributes to its therapeutic action. Regulatory frameworks emphasize bioequivalence through in vivo pharmacokinetic studies. Advanced modeling approaches, such as PBPK, predict the drug's absorption, distribution, metabolism, and excretion (ADME). These models integrate in vitro dissolution data and formulation properties, optimizing product design and regulatory assessments while supporting personalized therapy.

References:

Hsieh, N.-H., Bois, F.Y., Tsakalozou, E., Ni, Z., Yoon, M., Sun, W., Klein, M., Reisfeld, B., & Chiu, W.A. (2021) A Bayesian Population Physiologically Based Pharmacokinetic Absorption Modeling Approach to Support Generic Drug Development: Application to Bupropion Hydrochloride Oral Dosage Forms, J Pharmacokinet Pharmacodyn.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For detailed information about Zyban 150 by GlaxoSmithKline (GSK), consult with your doctor or healthcare professional.

Products
Active Substances
  • Bupropion Hydrochloride
Common Names
  • Wellbutrin
 About Product
Zyban 150 mg 60 tablets Glaxosmithkline
GlaxoSmithKline (GSK)
International
$75.00
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FAQ
How is Bupropion Hydrochloride metabolized?
It is metabolized in the liver primarily through CYP2B6 hydroxylation and by carbonyl reductase enzymes.
References:

Hsieh, N.-H., Bois, F.Y., Tsakalozou, E., Ni, Z., Yoon, M., Sun, W., Klein, M., Reisfeld, B., & Chiu, W.A. (2021) A Bayesian Population Physiologically Based Pharmacokinetic Absorption Modeling Approach to Support Generic Drug Development: Application to Bupropion Hydrochloride Oral Dosage Forms, J Pharmacokinet Pharmacodyn.

What does bioequivalence (BE) mean for Bupropion products?
BE ensures that generic versions of Bupropion provide similar pharmacokinetic profiles to brand-name products, confirmed through FDA-recommended in vivo studies.
References:

Hsieh, N.-H., Bois, F.Y., Tsakalozou, E., Ni, Z., Yoon, M., Sun, W., Klein, M., Reisfeld, B., & Chiu, W.A. (2021) A Bayesian Population Physiologically Based Pharmacokinetic Absorption Modeling Approach to Support Generic Drug Development: Application to Bupropion Hydrochloride Oral Dosage Forms, J Pharmacokinet Pharmacodyn.

What is PBPK modeling, and how is it used for Bupropion?
Physiologically based pharmacokinetic (PBPK) modeling predicts the drug's behavior in the body by integrating drug properties and patient physiology, supporting drug development and regulatory decisions.
References:

Hsieh, N.-H., Bois, F.Y., Tsakalozou, E., Ni, Z., Yoon, M., Sun, W., Klein, M., Reisfeld, B., & Chiu, W.A. (2021) A Bayesian Population Physiologically Based Pharmacokinetic Absorption Modeling Approach to Support Generic Drug Development: Application to Bupropion Hydrochloride Oral Dosage Forms, J Pharmacokinet Pharmacodyn.