Yohimbine is a monoterpenoid indole alkaloid known for its stimulant and aphrodisiac effects, primarily used in the treatment of erectile dysfunction. First licensed in Canada (1951) and Germany (1978), it acts as an α2-adrenergic receptor antagonist, affecting both central and peripheral nervous systems. Yohimbine also interacts with serotonin and dopamine receptors, showing potential in various therapeutic areas such as cardiovascular health, inflammation, and even cancer. Despite minor side effects like anxiety or hypertension, it remains a well-studied and relatively safe compound with future promise in targeted therapies.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
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Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
Jabir, N.R., Firoz, C.K., Zughaibi, T.A., Alsaadi, M.A., Abuzenadah, A.M., Al-Asmari, A.I., Alsaieedi, A., Ahmed, B.A. and Ramu, A.K., 2022. A literature perspective on the pharmacological applications of yohimbine. Annals of Medicine.
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