Tadalafil citrate, known commercially as Cialis, began development in 1993 as IC351 and was later co-developed by Lilly ICOS LLC. It works by selectively inhibiting PDE5, increasing blood flow to treat erectile dysfunction. Its distinguishing feature is its extended duration of up to 36 hours, due to a unique molecular structure with a long half-life. Approved in Europe in 2002 and the U.S. in 2003, tadalafil offered a new level of convenience, allowing men greater flexibility and helping redefine sexual health treatment.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
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Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.