The GLP-1 hormone acts as an incretin, increasing insulin in a glucose-dependent manner, and therefore plays a key role in maintaining healthy blood sugar levels. Secreted by enteroendocrine L-cells, GLP-1 affects multiple bodily systems, influencing not only glucose metabolism but also appetite and inflammation. GLP-1 receptor (GLP-1R) activation, through GLP-1 agonists like exendin-4 and liraglutide, leads to increased intracellular signaling that drives insulin secretion, reduces glucagon, and supports beta-cell health. Its anti-inflammatory effects help decrease oxidative stress and cytokines, especially in cardiac tissues, adding benefits to cardiovascular and metabolic health therapies.
Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology
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Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology
Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology
Mehdi, S.F., Pusapati, S., Anwar, M.S., Lohana, D., Kumar, P., Nandula, S.A., Nawaz, F.K., Tracey, K., Yang, H., LeRoith, D., Brownstein, M.J. and Roth, J., 2023. Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent. Frontiers in Immunology
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