Known chemically as Sildenafil citrate, Viagra is a PDE5 inhibitor that became the first line of treatment for erectile dysfunction upon its 1998 release. Pfizer’s research aimed to develop a compound to prevent cGMP degradation, ensuring steady blood flow through smooth muscle relaxation. Originally targeting angina, its effects on blood flow led to repurposing for ED. With over 4,500 trial subjects, it demonstrated high efficacy and safety, achieving wide acceptance upon market release. Now a gold standard, Viagra has been prescribed to millions worldwide, significantly improving the quality of life for patients with ED.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
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Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.
Dunzendorfer, U. (2012) Sildenafil. Switzerland: Birkhäuser Basel.