Introduced in 2003 as Cialis, tadalafil became a cornerstone treatment for erectile dysfunction due to its long-acting effect and high PDE5 selectivity. Initially developed as IC351 by ICOS Corporation, the drug partnered into full development with Eli Lilly. Tadalafil’s 36-hour duration—enabled by its unique β-carboline structure and 17.5-hour half-life—provided unmatched flexibility. It quickly gained a reputation not just for potency, but for improving intimacy and spontaneity in relationships, shifting ED treatment from reactive to proactive care with its once-daily dosing option.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
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Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.
Coward, R.M. & Carson, C.C., 2008. Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management.