The pharmaceutical company Zeneca introduced anastrozole in the mid-1990s as a breakthrough in anti-estrogen therapy. Unlike tamoxifen, which blocks estrogen at the receptor, anastrozole acts upstream by inhibiting the enzyme aromatase, thereby reducing estrogen production itself. After gaining FDA approval in late 1995, its status was elevated following the results of the ATAC trial, which involved over 9,000 women and proved the drug's effectiveness in post-surgical breast cancer treatment. With these findings, it was rapidly integrated into clinical guidelines for hormone-sensitive cancer.
Llewellyn, W. (2017). William Llewellyn's Anabolics.
United States: Molecular Nutrition, LLC.
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Llewellyn, W. (2017). William Llewellyn's Anabolics.
United States: Molecular Nutrition, LLC.
Llewellyn, W. (2017). William Llewellyn's Anabolics.
United States: Molecular Nutrition, LLC.
Llewellyn, W. (2017). William Llewellyn's Anabolics.
United States: Molecular Nutrition, LLC.