Adalimumab is a crucial treatment for RA, offering significant relief from disease symptoms through its TNFα inhibition. However, its effectiveness is often compromised by immunogenicity, leading to the formation of ADAs that neutralize its activity. Conventional assays like ELISA frequently encounter issues such as false positives and negatives due to complex interferences, including immune complexes and rheumatoid factors. A novel flow cytometry-based assay addresses these challenges by reliably measuring both drug and ADA levels. This innovative approach highlights correlations between clinical markers like DAS28 scores and ADA presence, emphasizing the role of anti-hinge antibodies in mitigating ADA development. By refining therapeutic drug monitoring, this method supports optimized treatment strategies for RA patients.
Mian, A.S., Wallace, Z.S., and Wang, J., 2020. Immunogenicity and therapeutic drug monitoring of adalimumab in rheumatoid arthritis: A study of assay interference and novel detection methods. Journal of Immunology and Clinical Research.
Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.
For detailed information about Adalimumab 20 AMPULES by Swiss Remedies, consult with your doctor or healthcare professional.
Mian, A.S., Wallace, Z.S., and Wang, J., 2020. Immunogenicity and therapeutic drug monitoring of adalimumab in rheumatoid arthritis: A study of assay interference and novel detection methods. Journal of Immunology and Clinical Research.
Mian, A.S., Wallace, Z.S., and Wang, J., 2020. Immunogenicity and therapeutic drug monitoring of adalimumab in rheumatoid arthritis: A study of assay interference and novel detection methods. Journal of Immunology and Clinical Research.
Mian, A.S., Wallace, Z.S., and Wang, J., 2020. Immunogenicity and therapeutic drug monitoring of adalimumab in rheumatoid arthritis: A study of assay interference and novel detection methods. Journal of Immunology and Clinical Research.