Testosterone heptylate

Testosterone heptylate is a long-acting testosterone ester studied for its effects on skeletal muscle properties, particularly in conditions like hindlimb suspension (HS)-induced muscle atrophy. In a study on male rats, weekly high doses of testosterone heptylate (10 mg/kg) were administered alongside HS to evaluate changes in steroid receptor behavior in different muscle types. The findings revealed that testosterone treatment could not prevent the atrophy caused by HS, especially in slow-twitch muscles like the soleus (SOL). HS altered the fiber composition in SOL muscles, significantly reducing type I fibers and increasing type IIa and intermediate fibers. While testosterone treatment slightly affected fast-twitch muscles like the extensor digitorum longus (EDL), it did not restore muscle mass or fiber composition. HS and testosterone combined reduced the binding capacity and affinity of steroid receptors, with fast-twitch muscles showing higher sensitivity to testosterone. This suggests that mechanical factors and receptor sensitivity play critical roles in muscle response to testosterone heptylate.

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