Testosterone acetate is an esterified form of testosterone, known for its rapid action due to the short ester chain attached to the testosterone molecule, giving it a half-life of less than 24 hours. This makes testosterone acetate one of the fastest-acting testosterone esters available, with effects felt more quickly than longer esters like enanthate or cypionate. As an anabolic androgenic steroid, it serves as a prodrug, converting into active testosterone in the body, promoting muscle growth, recovery, and protein synthesis. Its androgenic properties support the development of male characteristics such as a deep voice, facial hair, and increased libido. Due to its fast absorption and metabolism, testosterone acetate requires more frequent administration than other esters, often needing daily or every-other-day injections to maintain stable testosterone levels. While its rapid effects are beneficial for users needing fast results, the frequent dosing can be seen as inconvenient compared to slower-releasing testosterone forms. Chemically, testosterone acetate is practically insoluble in water and has a unique crystallographic structure, crystallizing in the noncentrosymmetric orthorhombic P212121 space group. The crystal's stability is enhanced by bifurcated hydrogen bonding interactions involving the carbonyl oxygen of the ketone group, contributing to the overall stability of the crystalline form.
National Center for Advancing Translational Sciences (NCATS) (n.d.) 'Testosterone acetate', NCATS Inxight Drugs.
Turza, A., Popescu, V., Mare, L., & Borodi, G. (2022) 'Structural Aspects and Intermolecular Energy for Some Short Testosterone Esters', Materials (Basel).
Biosynth (n.d.) 'Testosterone acetate', Biosynth.
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Biosynth (n.d.) 'Testosterone acetate', Biosynth.
Biosynth (n.d.) 'Testosterone acetate', Biosynth.
Biosynth (n.d.) 'Testosterone acetate', Biosynth.