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Sargramostim

Sargramostim

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Sargamostim 0.25
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Substance Overview and History

Sargramostim, or recombinant human granulocyte-macrophage colony-stimulating factor (rhu GM-CSF), accelerates bone marrow recovery following damage from chemotherapy, radiation, or transplantation. Approved by the FDA in 1991, it promotes the production and function of various hematopoietic lineages. By modulating the innate and adaptive immune systems, sargramostim also enhances anti-cancer responses when combined with treatments like immune checkpoint inhibitors. Its ability to improve hematologic recovery while reducing infections and therapy-related toxicity highlights its significance in managing cancer and immune-related conditions.

References:


Lazarus, H.M., Ragsdale, C.E., Gale, R.P., and Lyman, G.H., 2021. Sargramostim (rhu GM-CSF) as cancer therapy (systematic review) and an immunomodulator: A drug before its time? Frontiers in Immunology.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is sargramostim?
Sargramostim is a recombinant human granulocyte-macrophage colony-stimulating factor (rhu GM-CSF) used to stimulate bone marrow recovery and enhance immune responses.
References:


Lazarus, H.M., Ragsdale, C.E., Gale, R.P., and Lyman, G.H., 2021. Sargramostim (rhu GM-CSF) as cancer therapy (systematic review) and an immunomodulator: A drug before its time? Frontiers in Immunology.

What are the primary uses of sargramostim?
Sargramostim is primarily used to accelerate hematologic recovery after chemotherapy, radiation, or bone marrow transplantation and to reduce therapy-related infections and toxicity.
References:


Lazarus, H.M., Ragsdale, C.E., Gale, R.P., and Lyman, G.H., 2021. Sargramostim (rhu GM-CSF) as cancer therapy (systematic review) and an immunomodulator: A drug before its time? Frontiers in Immunology.

How does sargramostim work?
Sargramostim stimulates the production and function of various hematopoietic cells and modulates the innate and adaptive immune systems to enhance immune responses.
References:


Lazarus, H.M., Ragsdale, C.E., Gale, R.P., and Lyman, G.H., 2021. Sargramostim (rhu GM-CSF) as cancer therapy (systematic review) and an immunomodulator: A drug before its time? Frontiers in Immunology.