Rosuvastatin

Rosuvastatin calcium, a potent statin for managing dyslipidaemia, has low solubility and oral bioavailability, posing challenges for effective drug delivery. Developing amorphous rosuvastatin calcium tablets using the direct compression method enhances dissolution and bioavailability. The amorphous form, characterized by higher solubility than crystalline forms, was stabilized using alkalinizing agents like calcium carbonate and water-soluble diluents such as lactose monohydrate. Advanced techniques, including SEM, DSC, and FT-IR, ensured compatibility between active ingredients and excipients, optimizing the formulation to meet pharmacopoeial standards for quality and performance.

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