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Retinoic acid

Retinoic acid

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Substance Overview and History

Retinoic acid, a metabolite of vitamin A, is essential for skin health and cellular function. Known for its therapeutic properties, all-trans-retinoic acid (ATRA) regulates cell growth and differentiation. It is widely used to treat conditions like acne, psoriasis, and skin cancers, as well as acute promyelocytic leukemia (APL). Retinoids are classified into generations based on structure, from naturally occurring non-aromatic compounds to synthetic derivatives. Their function is mediated through retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which control gene expression essential for skin development. ATRA's rapid metabolism by cytochrome P450 enzymes creates a feedback loop that regulates its activity, underscoring its role in maintaining skin health and treating dermatological diseases.

References:


Szymański, Ł., Skopek, R., Palusińska, M., Schenk, T., Stengel, S., Lewicki, S., Kraj, L., Kamiński, P. and Zelent, A., 2020. Retinoic acid and its derivatives in skin. Cells

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is retinoic acid?
Retinoic acid is an active metabolite of vitamin A that plays a key role in regulating cell growth, differentiation, and immune function, particularly in the skin.
References:


Szymański, Ł., Skopek, R., Palusińska, M., Schenk, T., Stengel, S., Lewicki, S., Kraj, L., Kamiński, P. and Zelent, A., 2020. Retinoic acid and its derivatives in skin. Cells

What are the primary uses of retinoic acid?
Retinoic acid is used to treat dermatological conditions such as acne, psoriasis, and skin cancers, and it is also applied in therapies for acute promyelocytic leukemia (APL).
References:


Szymański, Ł., Skopek, R., Palusińska, M., Schenk, T., Stengel, S., Lewicki, S., Kraj, L., Kamiński, P. and Zelent, A., 2020. Retinoic acid and its derivatives in skin. Cells

How does retinoic acid work in the skin?
It binds to retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which act as molecular switches to regulate gene expression involved in cell growth and repair.
References:


Szymański, Ł., Skopek, R., Palusińska, M., Schenk, T., Stengel, S., Lewicki, S., Kraj, L., Kamiński, P. and Zelent, A., 2020. Retinoic acid and its derivatives in skin. Cells