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Paracetamol

Paracetamol

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Substance Overview and History

Paracetamol, widely used for fever and pain relief, is often considered a safe medication. However, emerging research highlights its potential to cause significant hypotension, particularly in febrile and critically ill patients. This effect is most pronounced when administered parenterally, where continuous haemodynamic monitoring often detects persistent blood pressure reductions. Outside critical care settings, delayed detection of paracetamol-induced hypotension poses risks, especially for high-risk patients. Despite evidence of this adverse effect, pharmaceutical disclosures remain inadequate, necessitating greater awareness among healthcare professionals to ensure timely detection and intervention.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is paracetamol primarily used for?
Paracetamol is commonly used to alleviate pain and reduce fever in various medical and home care settings.
Can paracetamol cause hypotension?
Yes, paracetamol can lead to low blood pressure, particularly in febrile and critically ill patients, especially with intravenous administration.
Who is most vulnerable to paracetamol-induced hypotension?
Critically ill patients with fever, sepsis, or shock are at the highest risk of experiencing significant blood pressure drops following paracetamol use.