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Naproxen

Naproxen

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Naproxen 220
Swiss Remedies
Substance Overview and History

Naproxen, a common non-steroidal anti-inflammatory drug (NSAID), has shown promising antiviral activity against SARS-CoV-2. Beyond inhibiting COX-1 and COX-2 to control inflammation, it binds to the viral nucleoprotein (N), disrupting its RNA-binding and oligomerization essential for replication. Studies in cell models demonstrated that naproxen significantly reduced viral replication and protected bronchial epithelial cells from SARS-CoV-2-induced damage. Its dual-action properties make it a potential therapeutic candidate for COVID-19.

References:

Terrier, O., Dilly, S., Pizzorno, A., Chalupska, D., Humpolickova, J., Bouřa, E., Berenbaum, F., Quideau, S., Lina, B., Fève, B., Adnet, F., Sabbah, M., Rosa-Calatrava, M., Maréchal, V., Henri, J., and Slama-Schwok, A., 2021. Naproxen exhibits antiviral and anti-inflammatory properties against SARS-CoV-2. Molecules.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is naproxen used for?
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever.
References:

Terrier, O., Dilly, S., Pizzorno, A., Chalupska, D., Humpolickova, J., Bouřa, E., Berenbaum, F., Quideau, S., Lina, B., Fève, B., Adnet, F., Sabbah, M., Rosa-Calatrava, M., Maréchal, V., Henri, J., and Slama-Schwok, A., 2021. Naproxen exhibits antiviral and anti-inflammatory properties against SARS-CoV-2. Molecules.

How does naproxen work as an antiviral?
Naproxen binds to the nucleoprotein (N) of SARS-CoV-2, disrupting viral RNA binding and oligomerization, which are critical for viral replication.
References:

Terrier, O., Dilly, S., Pizzorno, A., Chalupska, D., Humpolickova, J., Bouřa, E., Berenbaum, F., Quideau, S., Lina, B., Fève, B., Adnet, F., Sabbah, M., Rosa-Calatrava, M., Maréchal, V., Henri, J., and Slama-Schwok, A., 2021. Naproxen exhibits antiviral and anti-inflammatory properties against SARS-CoV-2. Molecules.

Does naproxen help against COVID-19?
Studies suggest naproxen inhibits SARS-CoV-2 replication and reduces epithelial damage, combining antiviral and anti-inflammatory effects that may benefit COVID-19 patients.
References:

Terrier, O., Dilly, S., Pizzorno, A., Chalupska, D., Humpolickova, J., Bouřa, E., Berenbaum, F., Quideau, S., Lina, B., Fève, B., Adnet, F., Sabbah, M., Rosa-Calatrava, M., Maréchal, V., Henri, J., and Slama-Schwok, A., 2021. Naproxen exhibits antiviral and anti-inflammatory properties against SARS-CoV-2. Molecules.