Epistane, also known as methylepitiostanol, is a 17-alpha-alkylated derivative of epitiostanol, originally developed in Japan as a treatment for breast cancer. It functions as both an androgen and a steroidal antiestrogen, offering unique dual-action properties. However, its use may inhibit the hypothalamic-pituitary-gonadal axis, potentially leading to anabolic steroid-induced hypogonadism (ASIH). As a methylated compound, it carries a risk of hepatotoxicity. This substance has been detected in dietary supplements, with potential to degrade into the controlled anabolic steroid desoxymethyltestosterone (Madol).
Rahnema, C.D., Crosnoe, L.E. and Kim, E.D. (2015), Designer steroids – over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology.
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Rahnema, C.D., Crosnoe, L.E. and Kim, E.D. (2015), Designer steroids – over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology.
Rahnema, C.D., Crosnoe, L.E. and Kim, E.D. (2015), Designer steroids – over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology.
Rahnema, C.D., Crosnoe, L.E. and Kim, E.D. (2015), Designer steroids – over-the-counter supplements and their androgenic component: review of an increasing problem. Andrology.
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