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Lacidipine

Lacidipine

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Lacipil 4
GlaxoSmithKline (GSK)
Substance Overview and History

Lacidipine, a calcium channel blocker, exhibits significant anti-atherosclerotic effects in early vascular disease by preventing intimal thickening and improving vascular function. In a rabbit model of collar-induced atherosclerosis, lacidipine reduced pathological changes without the presence of hypercholesterolemia or hypertension. It normalized vascular reactivity, decreasing serotonin sensitivity and enhancing nitric oxide-mediated endothelium-dependent relaxation. Unlike traditional treatments focused on lipid metabolism, lacidipine’s effects were independent of changes in oxidant stress markers like nitrotyrosine or modulation of matrix metalloproteinase-9 (MMP-9). Its protective properties highlight its ability to target vascular remodeling directly through mechanisms associated with endothelial health and nitric oxide bioavailability, offering promise for managing atherosclerosis early.

References:

Yetik, G., Üstünes, L., Dilsiz, O.Y., & Ergul, A. (2010) 'Lacidipine has anti-atherosclerotic effects independent of its actions on lipid metabolism and blood pressure', Vascular Pharmacology.

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Lacidipine used for?
Lacidipine is a calcium channel blocker primarily used to treat hypertension and manage cardiovascular conditions.
References:

Yetik, G., Üstünes, L., Dilsiz, O.Y., & Ergul, A. (2010) 'Lacidipine has anti-atherosclerotic effects independent of its actions on lipid metabolism and blood pressure', Vascular Pharmacology.

How does Lacidipine help in atherosclerosis?
Lacidipine prevents intimal thickening, improves vascular function, and enhances nitric oxide-mediated endothelium-dependent relaxation in early atherosclerosis.
References:

Yetik, G., Üstünes, L., Dilsiz, O.Y., & Ergul, A. (2010) 'Lacidipine has anti-atherosclerotic effects independent of its actions on lipid metabolism and blood pressure', Vascular Pharmacology.

Does Lacidipine require high cholesterol levels to be effective?
No, studies show that Lacidipine’s protective effects occur even in the absence of hypercholesterolemia, focusing on vascular health rather than lipid levels.
References:

Yetik, G., Üstünes, L., Dilsiz, O.Y., & Ergul, A. (2010) 'Lacidipine has anti-atherosclerotic effects independent of its actions on lipid metabolism and blood pressure', Vascular Pharmacology.