Esomeprazole, a proton pump inhibitor, is widely used to manage acid-related conditions like gastroesophageal reflux disease and NSAID-induced ulcers. Beyond suppressing gastric acid, it offers protective effects on the gastric mucosa by reducing oxidative damage, inhibiting inflammation, and modulating NF-κB and p38 MAPK pathways. In stress ulcers, esomeprazole elevates gastric pH, reduces pepsin secretion, and balances antioxidant levels by lowering ROS, SOD, and GSH. It also suppresses TNF-α and IL-1β, mitigating inflammation and cellular damage in gastric tissues.
Xie, W., Huang, X., Chen, R., Chen, R., Li, T., Wu, W., & Huang, Z. (2019) Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways. Drug Design, Development and Therapy.
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Xie, W., Huang, X., Chen, R., Chen, R., Li, T., Wu, W., & Huang, Z. (2019) Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways. Drug Design, Development and Therapy.
Xie, W., Huang, X., Chen, R., Chen, R., Li, T., Wu, W., & Huang, Z. (2019) Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways. Drug Design, Development and Therapy.
Xie, W., Huang, X., Chen, R., Chen, R., Li, T., Wu, W., & Huang, Z. (2019) Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways. Drug Design, Development and Therapy.
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