My account
Injectables Orals Peptides Human Growth Hormone SARMs
Sign in
A
Anastrozole
B
Bacteriostatic water Boldenone undecylenate
C
Clenbuterol Clomiphene citrate Cabergoline
D
Drostanolone enanthate Drostanolone propionate Dehydroepiandrosterone (DHEA)
E
Erythropoietin Exemestane
F
Fluoxymesterone
H
Human chorionic gonadotropin Human growth hormone
L
Liothyronine sodium
M
Mecasermin Meldonium Mesterolone Methandienone Methenolone acetate Methenolone enanthate Melanotan-2
N
Nandrolone decanoate Nandrolone phenylpropionate
O
Oxandrolone Oxymetholone
S
Sildenafil citrate Stanozolol
T
Trenbolone enanthate Trestolone acetate Trenbolone acetate Testosterone undecanoate Testosterone propionate Testosterone base and suspension Tadalafil citrate Testosterone cypionate Testosterone enanthate Tamoxifen citrate Turinabol
Y
Yohimbine
Show 164 results
Manufacturers
Categories
Substances
Disagree
Home Substances
Amoxicillin

Amoxicillin

A-Z
Search for:
Substance Overview and History

Amoxicillin is a semisynthetic penicillin commonly used for its broad-spectrum bactericidal properties. However, its susceptibility to beta-lactamases limits its effectiveness against resistant pathogens. To address this, it is often combined with sulbactam, a beta-lactamase inhibitor. Recent studies have explored hybrid molecules that link amoxicillin and sulbactam via methylene bridges, creating compounds with promising applications in veterinary medicine. These hybrids, after administration, metabolize into active forms like amoxicilloic acid and amoxicillin diketopiperazine. While the excretion rates in urine and feces are similar to those of the non-hybrid mixtures, these compounds show slower elimination from the liver and kidney. This delayed elimination may enhance their efficacy against infections, presenting a novel approach to combating antimicrobial resistance.

References:

Zhao, F., Sun, X., Li, J., Du, J., Wu, Z., Liu, S., Chen, L., & Fang, B. (2024). A comprehensive study to determine the residual elimination pattern of major metabolites of amoxicillin–sulbactam hybrid molecules in rats by UPLC–MS/MS. Molecules. 

Disclaimer: Information provided it this page is for general information only and does not substitute for professional medical advice.

For more details consult with your doctor or healthcare professional.

FAQ
What is Amoxicillin, and how does it work?
Amoxicillin is a broad-spectrum semisynthetic penicillin that kills bacteria by inhibiting cell wall synthesis, making it effective against various Gram-positive and Gram-negative pathogens.
References:

Zhao, F., Sun, X., Li, J., Du, J., Wu, Z., Liu, S., Chen, L., & Fang, B. (2024). A comprehensive study to determine the residual elimination pattern of major metabolites of amoxicillin–sulbactam hybrid molecules in rats by UPLC–MS/MS. Molecules. 

Why is Amoxicillin combined with sulbactam?
Sulbactam inhibits beta-lactamase enzymes that can degrade amoxicillin. This combination extends amoxicillin's activity to beta-lactamase-producing resistant bacteria.
References:

Zhao, F., Sun, X., Li, J., Du, J., Wu, Z., Liu, S., Chen, L., & Fang, B. (2024). A comprehensive study to determine the residual elimination pattern of major metabolites of amoxicillin–sulbactam hybrid molecules in rats by UPLC–MS/MS. Molecules. 

What are Amoxicillin–sulbactam hybrid molecules?
These are compounds linking amoxicillin and sulbactam via methylene bridges. They metabolize into active forms, enhancing their antibacterial effects and resistance to enzymatic degradation.
References:

Zhao, F., Sun, X., Li, J., Du, J., Wu, Z., Liu, S., Chen, L., & Fang, B. (2024). A comprehensive study to determine the residual elimination pattern of major metabolites of amoxicillin–sulbactam hybrid molecules in rats by UPLC–MS/MS. Molecules.